Like Hyde Park, Roxbury and East Boston, social isolation in Mattapan is correlated with all of the social determinants of vulnerability. People of color who rented and had a disability are the most vulnerable populations in this neighborhood. These populations were correlated with all other social factors and each other (r ≥ 0.712, P < 0.05). Mattapan had two groups that had the second largest percentage of people compared to other neighborhoods: people who were socially isolated and people with limited English proficiency. Additionally, this neighborhood had the largest percentage of people with disabilities, children, and people of color (over 95%).