The Fenway/Kenmore Square neighborhood had two groups of people who were most socially vulnerable. First, low-income households that rent, do not have a vehicle, and have limited English proficiency (r ≥ 0.764, P < 0.01). The second group is older adults with a disability and limited English proficiency (r ≥ 0.73, P < 0.01). Certain vulnerable groups exist in smaller numbers in this neighborhood. Fenway had the smallest percentages of social isolation, children, and older adults. Additionally, it had the second smallest percentages of people with disabilities and without a high school education. The existence of smaller numbers of certain vulnerable groups suggests the second cluster may be a relatively small group of people.