Social isolation in East Boston was highly correlated with all of the social characteristics. The most socially vulnerable households in East Boston were likely to include all or some combination of the following: having disabilities, households with children, low-to-no income, limited English Proficiency, women, renters, medical illness, and no vehicle (r ≥ 0.703, P < 0.01). Census tract 501.01 had a high concentration of people of color, with limited English proficiency, disabilities, low-to-no income, children, and less than a high school education. This census tract is in the Eagle Hill area where East Boston High School is located. Overall, East Boston had the largest percentage of people without a high school education.